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The plant research may also apply the findings to humans or animals because both use similar sugar transporter genes to transfer glucose, leading to new possibilities for medicine and diabetes research.
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Source: Frank White Kansas State University. Molecular Prosthesis Against Gout. Researchers from the ETH Zurich's Department of Biosystems Science and Engineering D-BSSE have devised a new method for preventing and permanently eradicating the cause of gout.
It involves implanting a biological network that regulates the uric acid levels autonomously. As Paracelsus once stated, the dose makes the poison.
This not only goes for chemical substances introduced to the body, but also those produced by it. The uric acid in the blood especially needs to be in the proper dosage.
If the level is too high i. However, uric acid is an important part of the human detoxification system, acting as a so-called "scavenger" of free radicals, which cause neurological disorders, brain diseases and tumors.
A team of re-searchers headed by Professor Martin Fussenegger from ETH Zurich's D-BSSE in Basle has now succeeded in building a network of genes which permanently keep the uric acid concentration in check.
The preliminary trials in mice have been encouraging. The research results will be published on Sunday in the journal Nature Biotechnology.
Self-regulating network In most mammals, the enzyme urate oxydase controls the uric acid level. As humans evolved from the apes, however, they lost this enzyme, which is why we suffer more from an elevated uric acid concentration.
Researchers from ETH Zurich set about finding a way to rectify the defect and restore the subtle control of the uric acid level.
With this in mind, they put together a biological network of genes called UREX. The individual components of UREX were "programmed" differently by the researchers: a uric acid sensor constantly gauges and controls the concentration in the blood.
If the uric acid level reaches an alarming concen-tration, the sensor relays the information to a genetic circuit. This then makes sure that the third component of the network releases the correct amount of urate oxydase into the blood and that the uric acid level is restored to a healthy balance.
The three components of the network thus communicate with each other and work independently and automatically without any external assistance.
The uric acid level can therefore be controlled permanently using UREX. Genes left untouched The gene network is integrated in a single cell.
Around two million of these cells are enclosed in a seaweed gelatine capsule measuring 0. Pores in the capsule ensure that the cell receives an optimal supply of nutrients, the uric acid level can be gauged by the sensor and the enzyme can find its way into the blood.
However, the organism does not come into contact with the network's modified genes. Even if the method were used in humans, a direct intervention in the patient's genetic make-up would not be necessary.
However, this also raises concerns as the material can no longer be removed", explains Martin Fussenegger. But this is not the case with the new method: the implant can be removed safely at any time and without any after-effects.
For the ETH-Zurich professor, the result is a prime example of what the relatively new research branch of synthetic biology can achieve: "Many medical problems are solved by introducing chemical substances, i.
In our method, we repair a defective metabolic pathway and help the body to treat itself in the best possible way. There are many causes for the increase in the uric acid level: a genetic predisposition, environmental influences or an unbalanced diet.
Moreover, it can lead to so-called tumor lysis syndrome after chemotherapy. Due to the intervention, tumor cells disintegrate so quickly that too much uric acid finds its way into the blood.
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The team began its new tenure in the top-flight by winning its first three games; the winning streak ended with a tie against Real Madrid at El Madrigal, though the team was undefeated until falling to Real Betis 1—0 in the seventh matchday of the season.
The Yellow Submarine finished the —14 campaign in sixth, thus qualifying them for next season's Europa League. In —15 , Villarreal again finished the year in sixth, enough to secure direct qualification to the Europa League group stage.
In the —16 season, Villarreal led La Liga for the first time during the sixth and seventh weeks, before falling to fifth place the following week.
The club progressed to the semi final Europa League , but were knocked out 3—1 on aggregate by Liverpool. Villarreal led the first leg 1—0, but lost 3—0 in Liverpool.
They also rival Valencia , since the two had been the most competitive teams of the Valencian Community ; this clash is called the " Derbi de la Comunitat.
The club's famous yellow kit dates back to With the new season fast approaching, the son of the then Villarreal president travelled to Valencia to purchase replacements of the club's official kit of white shirts and black shorts.
Discovering that the shop had neither in stock, he instead bought the only colour that they did have, which happened to be yellow. The players voted that they should be dyed blue.
From to 30 June , the shirt sponsor was "Aeroport Castello", an airport. The current shirt sponsor is Pamesa, a ceramics company. From the —17 season, the kit is made by Joma , having previously been produced by the Chinese company Xtep and Puma of Germany among others.
The mascot named Groguet , "Little Yellow" is characterised as an anthropomorphic submarine. He made his debut on 26 October and was named on 13 December that year by a local year-old, Javier Fuster Almela, following a province-wide competition open to unders.
Players may hold more than one non-FIFA nationality. From Wikipedia, the free encyclopedia. Home colours. Away colours. Third colours.
Main article: Villarreal CF in European competitions. Main article: Villarreal CF in European football. Main article: Villarreal CF B. Further information: Villarreal CF women.
Retrieved 24 January The Independent. London: Perseverance Works. Villarreal CF. Derbi de la Comunitat. Yellow Submarine CD Roda.
Category Category. La Liga. Richest clubs: Deloitte list Forbes' list Team owners. Winning managers. Hidden categories: CS1 Spanish-language sources es Use dmy dates from April Pages using infobox football club with unknown parameters Articles containing Valencian-language text Commons category link from Wikidata Official website different in Wikidata and Wikipedia Articles with Spanish-language sources es Articles with Catalan-language sources ca.
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